Publications & Scientific References - Scantox (2024)

Test publicationDiscovery, Regulatory ToxicologyBonesKeyowrds Cancer2024

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Some analysis methidBiomarkerCell lineDOIURL.comdiscovery regulatory-toxicologybonescancercell-lineBiodistribution, persistence and lack of integration of a multigene HIV vaccine delivered by needle-free intradermal injection and electroporationDiscoveryElectroporation; Skin; Dermal; HIV; Plasmid; DNA; BiojectHIV2010

Andreas Bråve ^{a b}, Lindvi Gudmundsdotter ^{a b}, Eric Sandström ^c, B. Kristian Haller ^d, David Hallengärd ^{a b}, Anna-Karin Maltais ^e, Alan D. King ^f, Richard R. Stout ^g, Pontus Blomberg ^h, Urban Höglund ⁱ, Bo Hejdeman ^c, Gunnel Biberfeld ^a, Britta Wahren ^{a b}

a – Swedish Institute for Infectious Disease Control, Solna, Sweden
b – Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
c- Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden
d – Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
e – Cyto Pulse Sciences Inc., Solna, Sweden
f – Cellectis Bioresearch, Inc., Glen Burnie MD, USA
g – Bioject Medical Technologies, Tualatin, OR, USA
h – Vecura, Karolinska University Hospital, Huddinge, Sweden
i – Visionar Preclinical AB, Uppsala, Sweden

Mice10.1016/j.vaccine.2010.08.108www.sciencedirect.com/science/article/pii/S0264410X10014489?via%3DihubdiscoveryhivmiceThe Use of Minipigs in Non-Clinical ResearchRegulatory ToxicologyOther2013

Peter Glerup, Nanna Grand, Mikala Skydsgaard

Scantox A/S, Lille Skensved, Denmark

Göttingen Minipig10.1016/B978-0-12-415759-0.00013-3www.researchgate.net/publication/285181945_The_Use_of_Minipigs_in_Non-Clinical_Researchregulatory-toxicologyothergottingen-minipigRepeated measurements of motor activity in rats in long-term toxicity studiesRegulatory ToxicologyOther2014

V. Golozoubova, T.K. Brodersen, S. Klastrup, M. Oksama, J. Løgsted, A. Makin

Scantox A/S, Lille Skensved, Denmark

Rats10.1016/j.vascn.2014.06.007www.sciencedirect.com/science/article/abs/pii/S105687191400224X?via%3Dihubregulatory-toxicologyotherratsTransepidermal water loss and tape stripping in minipig skinRegulatory ToxicologyOther2015

A. Makin, Sisse Ellemann-Laursen, Nanna Grand, Gitte Jeppesen, T. Starostka, J. Løgsted, K. Kaaber

Göttingen Minipig10.1016/j.toxlet.2015.08.781www.researchgate.net/publication/282527493_Transepidermal_water_loss_and_tape_stripping_in_minipig_skinregulatory-toxicologyothergottingen-minipigThree-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal CancerDiscoveryCancer2015

Wojciech Senkowski; Xiaonan Zhang; Maria Hägg Olofsson; Ruben Isacson; Urban Höglund; Mats Gustafsson; Peter Nygren; Stig Linder; Rolf Larsson; Mårten Fryknäs

Uppsala University, Klinisk Farmakologi, ing 61 4tr, Dag Hammarskjölds Väg 18, 751 85 Uppsala, Sweden

Mice10.1158/1535-7163.MCT-14-0792aacrjournals.org/mct/article/14/6/1504/92034/Three-Dimensional-Cell-Culture-Based-ScreeningdiscoverycancermiceChanges in energy metabolism due to acute rotenone-induced mitochondrial complex I dysfunction – Anin vivolarge animal modelDiscoveryOther2016

Michael Karlsson ^{a b 1}, Johannes K. Ehinger ^{a b 1}, Sarah Piel ^{a b}, Fredrik Sjövall ^a, Johanna Henriksnäs ^c, Urban Höglund ^c, Magnus J. Hansson ^{a b}, Eskil Elmér ^{a b}

a – Mitochondrial Medicine, Department of Clinical Sciences, Lund University, BMC A13, SE-221 84 Lund, Sweden
b – NeuroVive Pharmaceutical AB, Medicon Village, Scheelevägen 2, SE-233 81 Lund, Sweden
c – Scantox Solna (Adlego Biomedical AB), P.O. Box 42, SE-751 03 Uppsala, Sweden

Göttingen Minipig10.1016/j.mito.2016.10.003www.sciencedirect.com/science/article/abs/pii/S1567724916302082?via%3Dihubdiscoveryothergottingen-minipigIn Vivo Electroporation Enhances the Immunogenicity of Hepatitis C Virus Nonstructural 3/4A DNA by Increased Local DNA Uptake, Protein Expression, Inflammation, and Infiltration of CD3+T CellsDiscoveryHepatitis C

Gustaf Ahlén; Jonas Söderholm; Torunn Tjelle; Rune Kjeken; Lars Frelin; Urban Höglund; Pontus Blomberg; Michael Fons; Iacob Mathiesen; Matti Sällberg

Division of Clinical Microbiology, F68, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden

MiceOnline ISSN: 1550-6606journals.aai.org/jimmunol/article/179/7/4741/37980/In-Vivo-Electroporation-Enhances-thediscoveryhepatitis-cmiceBladder cancer therapy without toxicity—A dose-escalation study of alpha1-oleateDiscoveryCancer2020

Pham-Tue-Hung Tran¹, Naveed Asghar¹, Urban Höglund², Olivia Larsson², Lars Haag³, Ali Mirazimi^4,5, Magnus Johansson¹, Wessam Melik¹

¹ – School of Medical Science, Inflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, 703 62 Örebro, Sweden
² – Scantox Solna (Adlego Biomedical AB), P.O. Box 42, 751 03 Uppsala, Sweden
³ – EM Unit (EMil), Department of Laboratory Medicine, Karolinska Institute, 171 77 Solna, Sweden
⁴ – Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden
⁵ – National Veterinary Institute, 751 89 Uppsala, Sweden

Mice10.3390/microorganisms8121890www.mdpi.com/2076-2607/8/12/1890discoverycancermiceDevelopment of an Experimental Ex Vivo Wound Model to Evaluate Antimicrobial Efficacy of Topical FormulationsDiscoveryantibiotics; antimicrobial; biofilm; burn; ex vivo;wound healing; wound model.Wound Healing2021

Madalene Å Andersson¹, Lone Bruhn Madsen², Artur Schmidtchen ^3,4,5, Manoj Puthia⁵

¹ – In2Cure AB, Medicon Village, SE-22381 Lund, Sweden.
² – Scantox Lund (Timeline Bioresearch), Medicon Village, SE-22363 Lund, Sweden.
³ – Copenhagen Wound Healing Center, Bispebjerg Hospital, Department of Biomedical Sciences, University of Copenhagen, DK-2400 Copenhagen, Denmark.
⁴ – Dermatology, Skåne University Hospital, SE-22185 Lund, Sweden.
⁵ – Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-22184 Lund, Sweden.

Göttingen Minipig10.3390/ijms22095045pubmed.ncbi.nlm.nih.gov/34068733/discoverywound-healinggottingen-minipigProbing Skin Barrier Recovery on Molecular Level Following Acute Wounds: An In Vivo/Ex Vivo Study on Pigsacute wound; histology; in vivo/ex vivo; lipid; pH; polarization transfer solid state NMR (PTssNMR); skin barrier; small and wide-angle X-ray diffraction (SWAXD); stratum corneum; trans-epidermal water loss (TEWL).Wound Healing2021

Enamul Haque Mojumdar ^{1, 2},Lone Bruhn Madsen³,Henri Hansson⁴,Ida Taavoniku³,Klaus Kristensen³, Christina Persson⁵,Anna Karin Morén⁴,Rajmund Mokso⁶,Artur Schmidtchen⁷,Tautgirdas Ruzgas^{1, 2},Johan Engblom^{1, 2}

¹ – Department of Biomedical Science, Faculty of Health and Society, Malmö University, SE-205 06 Malmö, Sweden.
² – Biofilms-Research Center for Biointerfaces (BRCB), Malmö University, SE-205 06 Malmö, Sweden.
³ – Scantox Lund (Timeline Bioresearch AB), Scheelevägen 2, SE-223 63 Lund, Sweden.
⁴ – Galenica AB, Medeon Science Park, SE-205 12 Malmö, Sweden.
⁵ – Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, SE-205 02 Malmö, Sweden.
⁶ – Department of Solid Mechanics & MAX IV Laboratory, Lund University, SE-221 00 Lund, Sweden.
⁷ – Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden.
8 – Copenhagen Wound Healing Center, Bispebjerg Hospital, Department of Biomedical Sciences, University of Copenhagen, DK-2400 Copenhagen, Denmark.

Göttingen Minipig10.3390/biomedicines9040360pubmed.ncbi.nlm.nih.gov/33807251/wound-healinggottingen-minipigBehavioral Biology of Pigs and MinipigsRegulatory ToxicologyOther2021

Sandra Edwards, Nanna Grand

Göttingen MinipigBook: Behavioral Biology of Laboratory Animals, ISBN: 9780429019517www.taylorfrancis.com/chapters/edit/10.1201/9780429019517-17/behavioral-biology-pigs-minipigs-sandra-edwards-nanna-grand?context=ubx&refId=473a7a55-7628-4173-904a-641631685bdbregulatory-toxicologyothergottingen-minipigEnhanced Seroconversion to West Nile Virus Proteins in Miceby West Nile Kunjin Replicon Virus-like Particles Expressing Glycoproteins from Crimean–Congo Hemorrhagic Fever VirusDiscoveryOther2022

Pham-Tue-Hung Tran¹, Urban Höglund², Olivia Larsson², Sofia Appelberg³, Ali Murazimi^4,5, Magnus Johansson¹, Wessam Melin¹

¹ – School of Medical Science, Inflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, 703 62 Örebro, Sweden
² – Scantox Solna (Adlego Biomedical AB), P.O. Box 42, 751 03 Uppsala, Sweden
³ – Department of Microbiology, Public Health Agency of Sweden, 171 82 Solna, Sweden
⁴ – Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institution, 141 52 Huddinge, Sweden
⁵ – National Veterinary Institute, 751 89 Uppsala, Sweden

Mice10.3390/pathogens11020233www.mdpi.com/2076-0817/11/2/233discoveryothermiceMacromolecular Viral Entry Inhibitors as Broad‐SpectrumFirst‐Line Antivirals with Activity against SARS‐CoV‐2Discoverybroad‐spectrum antivirals, entry inhibitors, in vivo, macromolecules, polyanions, respiratory syncytial virus (RSV), SARS‐CoV‐2SARS-CoV2022

Rüdiger Groß¹, Lívia Mesquita Dias Loiola^2,3, Leila Issmail⁴, Nadja Uhlig⁴, Valentina Eberlein⁴, Carina Conzelmann¹, Lia‐Raluca Olari¹, Lena Rauch¹, Jan Lawrenz¹, Tatjana Weil¹, Janis A. Müller¹, Mateus Borba Cardoso³, Andrea Gilg¹, Olivia Larsson⁵, Urban Höglund⁵, Sandra Axberg Pålsson⁶, Anna Selch Tvilum², Kaja Borup Løvschall², Maria M. Kristensen², Anna‐Lena Spetz⁶, Fortune Hontonnou⁷, Marie Galloux⁷, Thomas Grunwald⁴, Alexander N. Zelikin², Jan Münch¹

¹ – Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081 Germany
² – Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus 8000 Denmark
³ – Brazilian Synchrotron Light Laboratory, Brazilian Center for Research in Energy and Materials, Campinas São Paulo, 13083‐970 Brazil
⁴ – Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig 04103 Germany
⁵ – Scantox Solna (Adlego Biomedical AB), Solna 171 65 Sweden
⁶ – Department of Molecular Biosciences, The Wenner‐Gren Institute Stockholm University, Stockholm 10691 Sweden
⁷ – Université Paris‐Saclay, INRAE, UVSQ, VIM, Jouy‐en‐Josas 78352 France

Mice10.1002/advs.202201378www.ncbi.nlm.nih.gov/pmc/articles/PMC9284172/discoverysars-covmiceA universal SARS-CoV DNA vaccine inducing highlycross-reactive neutralizing antibodies and T cellsDiscoverySARS-CoV2022

Sofia Appelberg ¹, Gustaf Ahlén², Jingyi Yan², Negin Nikouyan², Sofie Weber³, Olivia Larsson³, Urban Höglund³, Soo Aleman⁴, Friedemann Weber⁵, Emma Perlhamre⁶, Johanna Apro⁶, Eva‐Karin Gidlund⁷, Ola Tuvesson⁷, Simona Salati⁸, Matteo Cadossi⁸, Hanna Tegel⁹, Sophia Hober⁹, Lars Frelin², Ali Mirazimi1, and Matti Sällberg²

1 – Public Health Agency of Sweden Solna Sweden
² – Department of Laboratory Medicine Karolinska Institutet Huddinge Sweden
³ – Scantox Solna (Adlego AB) Uppsala Sweden
⁴ – Department of Infectious Disease Karolinska University Hospital Huddinge Sweden
⁵ – Institute for Virology, FB10‐Veterinary Medicine, Justus‐Liebing University Giessen Giessen Germany
⁶ – Karolinska Trial Alliance Karolinska University Hospital Huddinge Sweden
⁷ – NorthX Biologics Matfors Sweden
⁸ – IGEA Bomedical Spa Carpi Italy
⁹ – Department of Protein Science Royal Institute of Technology Stockholm Sweden

Mice10.15252/emmm.202215821www.embopress.org/doi/full/10.15252/emmm.202215821discoverysars-covmiceDevelopment of a Multivalent Kunjin Virus Reporter Virus-LikeParticle System Inducing Seroconversion for Ebola and West Nile Virus Proteins in MiceDiscoveryEbola2022

Pham-Tue-Hung Tran¹, Naveed Asghar¹, Urban Höglund², Olivia Larsson², Lars Haag³, Ali Mirazimim^4,5, Magnus Johansson¹, Wessam Melik¹

¹ – School of Medical Science, Inflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, 703 62 Örebro, Sweden
² – Scantox Solna (Adlego Biomedical AB), P.O. Box 42, 751 03 Uppsala, Sweden
³ – EM Unit (EMil), Department of Laboratory Medicine, Karolinska Institute, 171 77 Solna, Sweden
⁴ – Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden
⁵ – National Veterinary Institute, 751 89 Uppsala, Sweden

Mice10.3390/microorganisms8121890www.mdpi.com/2076-2607/8/12/1890discoveryebolamiceSpike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2antibodies, SARS – CoV – 2, antibody function,antibody binding, spike (S) protein, phagocytosis, in vivo modelSARS-CoV2021

Wael Bahnan¹, Sebastian Wrighton¹, Martin Sundwall¹, Anna Läckberg¹,², Olivia Larsson³, Urban Höglund³, Hamed Khakzad⁴,⁵, Magdalena Godzwon⁶, Maria Walle⁶, Elisabeth Elder⁷, Anna Söderlund Strand⁸, Lotta Happonen¹, Oscar André¹, Johannes Kumra Ahnlide¹, Thoms Hellmark⁹, Vidar Wendel-Hansen¹⁰, Robert P.A. Wallin¹¹, Johan Malmström¹, Lars Malmström¹,12, Mats Ohlin⁶,¹³, Magnus Rasmussen¹,², Pontus Nordenfelt¹

1 – Department of Clinical Sciences Lund, Infection Medicine, Faculty of Medicine, Lund University, Lund, Sweden
² – Infectious Disease Clinic, Skåne University Hospital, Lund, Sweden
³ – Scantox Solna (Adlego Biomedical AB), Uppsala, Sweden
⁴ – Equipe Signalisation Calcique et Infections Microbiennes, Ecole Normale Supérieure Paris-Saclay, Gif-sur-Yvette, France
⁵ – Institut National de la Santé et de la Recherche Médicale (INSERM) U1282, Gif-sur-Yvette, France
⁶ – Department of Immunotechnology, Lund University, Lund, Sweden
⁷ – Public Health Agency of Sweden, Solna, Sweden
⁸ – Department of Laboratory Medicine, Clinical Microbiology, Skane University Hospital Lund, Lund University, Lund, Sweden
⁹ – Department of Clinical Sciences Lund, Nephrology, Skane University Hospital Lund, Lund University, Lund, Sweden
¹⁰ – Tanea Medical Ab, Uppsala, Sweden
¹¹ – SciEd Solutions, Stockholm, Sweden
¹² – Institute for Computational Science, Zurich, Switzerland
¹³ – SciLifeLab Drug Discovery and Development, Lund University, Lund, Sweden

Mice10.3389/fimmu.2021.808932www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.808932/fullsars-covmiceThe Non-Human Primate in Safety Assessment of aBifunctional Long-Acting Insulin AnalogueRegulatory Toxicologynon-clinical development, non-human primates, minipigs, cynomolgus monkey, safety assessment, long-acting insulin, PCSK9iOther2023

Vivi FH Jensen DVM PhD¹, Nikolai K Jensen DVM¹, Line H Schefe PhD¹, Jens Sigh PhD¹, Akiyemi Akintomide MSc², Kari Kaaber DVM³, Sophia G Moesgaard DVM PhD⁴, Mona H Pedersen PhD¹

¹ – Global Drug Discovery and Development Sciences, Novo Nordisk A/S, Maaloev, Denmark
² – Labcorp Early Development Laboratories Limited, Huntingdon, UK
³ – Scantox A/S, Lille Skensved, Denmark
⁴ – Y-mAbs Therapeutics A/S, Hørsholm, Denmark

Other10.1177/10915818231156898journals.sagepub.com/doi/10.1177/10915818231156898regulatory-toxicologyotherotherAlginate and Nanocellulose Dressings With Extract FromSalmon Roe Reduce Inflammation and Accelerate Healing of Porcine Burn WoundsDiscoveryAnti-inflammatory agents, oxidative stress, inflammation, alginates, bandages, burns, interleukins, macrophages, salmon, suidae, swine, miniature, wound healing, dressing of skin or wounds, inflammatory response, partial thickness burnsWound Healing2023

Karin M Gilljam PhD, Patrik Stenlund PhD, Simon Standort MSc, Sisse Bindslev Andersen DVM,
Kari Kaaber DVM, Henrik Lund MD PhD, Karl R K Bryn MD

Göttingen Minipig10.1093/jbcr/irad006academic.oup.com/jbcr/article/44/5/1140/6987519?login=falsediscoverywound-healinggottingen-minipigSubclass-switched anti-spike IgG3 oligoclonal co*cktailsstrongly enhance Fc-mediated opsonizationDiscoveryFc-mediated function; affinity; oligoclonal; phagocytosis; subclass2023

Arman Izadi¹, Arsema Hailu¹, Magdalena Godwon², Sebastian Wrighton¹, Berit Olofsson¹, Tobias Schmidt^3,4, Anna Söderlund-Strand⁵, Elizabeth Elder⁶, Sofia Appelberg⁷, Maria Valsjö⁸, Olivia Larsson⁸, Vidar Wendel-Hansen9, Mats Ohlin^2,10, Wael Bahnan¹, Pontus Nordenfelt¹,⁵.

¹ – Department of Clinical Sciences Lund, Division of Infection Medicine, Faculty of Medicine, Lund University, 221 84 Lund, Sweden.
² – Department of Immunotechnology, Faculty of Engineering, Lund University, 221 00 Lund, Sweden.
³ – Department of Clinical Sciences Lund, Division of Pediatrics, Faculty of Medicine, Lund University, 221 84 Lund, Sweden.
⁴ – Wallenberg Center for Molecular Medicine, Faculty of Medicine, Lund University, 221 84 Lund, Sweden.
⁵ – Department of Laboratory Medicine, Clinical Microbiology, Skåne University Hospital Lund, Lund University, 221 85 Lund, Sweden.
⁶ – Department of Microbiology, National Veterinary Institute, 751 89 Uppsala, Sweden.
⁷ – Department of Microbiology, Public Health Agency of Sweden, 171 82 Stockholm, Sweden.
⁸ – Scantox A/S, 171 65 Stockholm, Sweden.
⁹ – Tanea Medical AB, 751 83 Uppsala, Sweden.
¹⁰ – SciLifeLab Drug Discovery and Development, Lund University, 221 00 Lund, Sweden.

pubmed.ncbi.nlm.nih.gov/37011197/discoveryIodine loaded nanoparticles with commercial applicabilityincrease survival in mice cancer models with low degree of side effectsDiscoverycytotoxic; drug delivery; molecular iodine; nanoparticles; side effects.Cancer2023

Torkel Falkenberg, Olivia Larsson, Bengt Hedin, Shigeru Shiraki, Takahisa Karita

Mice10.1002/cnr2.1843pubmed.ncbi.nlm.nih.gov/37269144/discoverycancermiceFirst virological and pathological study of Göttingen Minipigswith Dippity Pig Syndrome (DPS)Regulatory ToxicologyOther2023

Hina Jhelum, Nanna Grand, Kirsten Rosenmay Jacobsen, Sabrina Halecker, Michelle Salerno, Robert Prate, Luise Krüger, Yannick Kristiansen, Ludwig Krabben, Lars Möller, Michael Laue, Benedikt Kaufer, Kari Kaaber, Joachim Denner

Laboratory of Joachim Denner at the Robert Koch Institute and the Institute of Virology was supported by the Deutsche Forschungsgemeinschaft, TRR127.

Göttingen Minipig10.1371/journal.pone.0281521journals.plos.org/plosone/article?id=10.1371/journal.pone.0281521regulatory-toxicologyothergottingen-minipigComparison of efficacy between subcutaneous andintravenous application of moss-aGal in the mouse model of Fabry diseaseDiscoveryenzyme replacement therapy, Fabry disease, moss-aGal,subcutaneous applicationOther2023

Paulina Dabrowska-Schlepp¹, Andreas Busch¹, Jin-Song Shen², Rachel Y. Cheong³, Lone Bruhn Madsen³,
Daniel Mascher⁴, Raphael Schiffmann², Andreas Schlaaf¹

¹ – Eleva GmbH, Freiburg, Germany
² – Institute of Metabolic Disease, Baylor, Scott & White Research Institute, Dallas, Texas, USA
³ – Scantox Sweden (Previously Timeline Bioresearch AB), Lund, Sweden
⁴ – pharm-analyt Labor GmbH, Baden, Austria

Mice10.1002/jmd2.12393scantox.com/wp-content/uploads/2023/09/JIMD-Reports-2023-DabrowskaSchlepp.pdfdiscoveryothermice